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KMID : 0191120160310050724
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Journal of Korean Medical Science
2016 Volume.31 No. 5 p.724 ~ p.728
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Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjogren’s Syndrome
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Lee Jennifer
Koh Jung-Hee
Kwok Seung-Ki
Park Sung-Hwan
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Abstract
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This study was conducted to generate and validate a cross-culturally adapted Korean version of the xerostomia inventory (XI), an 11-item questionnaire designed to measure the severity of xerostomia. The original English version of the XI was translated into Korean according to the guidelines for cross-cultural adaptation of health-related quality-of-life measures. Among a prospective cohort of primary Sjogren’s syndrome (pSS) in Korea, 194 patients were analyzed. Internal consistency was evaluated by using Cronbach’s alpha, and test-retest reliability was obtained by using an intraclass correlation coefficient (ICC) analysis. Construct validity was investigated by performing a correlation analysis between XI total score and salivary flow rate (SFR). Cronbach’s alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72. Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman’s rho, ρ = ?0.515, ?0.447, and ?0.482, respectively; P < 0.001). The correlation analysis between the visual analogue scale (VAS) score of overall dryness and SFR indicated a smaller ρ value (?0.235 [P = 0.006], ?0.243 [P = 0.002], and ?0.252 [P = 0.003], respectively), which supports that XI more accurately reflects the degree of xerostomia in the pSS patients. In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.
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KEYWORD
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Xerostomia Inventory, Sjogren’s Syndrome, Cross-Cultural Adaptation
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